AKT1 and malignant peritoneal mesothelioma: In this context, we previously provided evidence of a cytoprotective/resistance mechanism arising towards miR-34a reconstitution in diffuse malignant peritoneal mesothelioma cells through the persistent activation of ERK1/2 and AKT signaling [35], a well known mechanism of resistance to tyrosine receptor kinase inhibitors [36,37].