Different studies are available about the utility of CRP to distinguish dogs with sepsis from dogs with sterile inflammation [55,56,57,58,59], but only a recent study demonstrated that PON1 may be useful to discriminate dogs with sepsis from dogs with non-septic inflammation, although ultimately, CRP and albumin may better predict the outcome [60] and no information is available about the utility of PCO in dogs as diagnostic or prognostic marker, differently from human medicine [28,29,32,54,61,62,63]. The gene discussed is CRP; the disease is Sepsis.