TFEB and Alzheimer disease: This result was consistent with the observation that TFEB transcription in microglia was impaired within 6–12 months after birth, when Aβ plaques began to accumulate in APP/PS mice, and with the observation that nuclear TFEB decreased with the progression of Braak stage, a classification of AD stages based on the brain distribution of neurofibrils in the human brain [47,48].