Hyogo et al. have proved that chronic Cd poisoning can result in the injury of liver and kidney and hemolysis of RBC with a subsequent anemia; although the iron accumulates in organs because of hemolysis, the normal function of erythropoietin (EPO) was suppressed by Cd, which failed to compensate for the hemolytic anemia [40]. This evidence concerns the gene EPO and anemia (phenotype).