Treatment with 5–10 μM 3-Br-5-OCH3, 3-Cl-5-OCF3, 3-Cl-5-CF3, and 3-Br-5-OCF3 (Figure 4A–D, respectively) inhibited the growth of SKBR3 breast cancer cells and, treatment-related growth and inhibition were significantly attenuated after the NR4A1 knockdown by RNAi (Figure 4E illustrates the effectiveness of RNAi in decreasing NR4A1 protein). The gene discussed is NR4A1; the disease is breast carcinoma.