In particular, Chang P. et al. [61] tested a deep-learning approach, enforced with CNN, on 259 MRI of gliomas and CNN was shown to have high accuracy in identifying isocitrate dehydrogenase mutations (94%), 1p/19q co-deletion (92%) and O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter methylation (83%) status. Here, MGMT is linked to central nervous system cancer.