Additionally, overexpression of different EMT-TFs, including Slug, Twist, Six1 and Snai1, promoted stemness and tumor initiation capacity [140,141,142,143], whilst EMT-TF knockout had a tumor-preventative effect (e.g., Slug-knockout mice were resistant to MMTV-Myc-induced tumor initiation) [144]. Here, SIX1 is linked to neoplasm.