Elevated expression levels of Nrg1 (p ≤ 0.0001), Nrg2 (p = 0.001) and Nrg3 (p ≤ 0.0001) were evident in RMT and HCC groups in 129Sv mice (Figure 11B–D). This evidence concerns the gene NRG2 and hepatocellular carcinoma.