As a general tendency, in the frontal cortex the expression of EGF family in RMT 129Sv mice was elevated both compared to HCC 129Sv (Egf, Tgfa, Nrg2) and RMT Bl6 (Egf, Nrg1, Nrg2, Erbb1, Erbb4) mice. The gene discussed is ERBB4; the disease is hepatocellular carcinoma.