As a general tendency, in the frontal cortex the expression of EGF family in RMT 129Sv mice was elevated both compared to HCC 129Sv (Egf, Tgfa, Nrg2) and RMT Bl6 (Egf, Nrg1, Nrg2, Erbb1, Erbb4) mice. This evidence concerns the gene EGFR and hepatocellular carcinoma.