CDK1 and lung cancer: Consistent with previous reports that CDC2 (CDK1) and cyclinB1 (CCNB1) are crucial to G2/M transition [27,28], CVB-D-induced G2/M arrest was confirmed by the decrease in G2/M-transition-related protein CDC2 and cyclin B1 in a dose-dependent manner in all lung cancer cells (Figure 1F).