BOC and colitis: Interestingly, the trypsin-like activity in the colonic tissue strongly correlated with the severity of inflammation in the acute phase of colitis at day 3 (rs = 0.725, p < 0.001 for the Boc-Gln-Ala-Arg-AMC substrate and rs = 0.753, p < 0.001 for the Tos-Gly-Pro-Arg- AMC substrate, Figure 3H,I).