BOC and colitis: Trypsin-like activity was significantly increased in full-thickness samples taken from the distal colon of post-colitis rats in two assays assessing the cleavage of two trypsin substrates, Boc-Gln-Ala-Arg-AMC and Tos-Gly-Pro-Arg-AMC, compared to healthy controls (0.87 (0.49–1.16) U/g versus 0.18 (0.25–0.12) U/g, p < 0.01 and 1.08 (0.54–1.73) U/g versus 0.16 (0.13–0.19) U/g, p < 0.01, respectively, n = 12 per group, Figure 3A,B).