Some monogenic diseases are expected to present reduced TCR-induced DAG signalling such as Zap-70 deficiency, interleukin-2-inducible T-cell kinase (ITK) deficiency, X-linked immunodeficiency with magnesium defect (XMEN) or Wiskott Aldrich syndrome (WAS), and thus may be in principle compensated by DGKα targeting. Here, ZAP70 is linked to X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia.