Their high specificity allows for the detection of cancer initiation (e.g., SPRY4-IT1) [254], progression (e.g., ATB) [255], metastasis (e.g., LINC00461, CCAT2 and H19) [256,257,258] and response to therapy (e.g., MALAT1 or HOTAIR) [77,259,260]. This evidence concerns the gene HOTAIR and cancer.