Numerous genes associated to various pathways are known and rapidly identified; actually, genes involved in signal transduction (APC), DNA repair (MGMT, MLH1, BRCA1), detoxification (GSTP1), cell cycle regulation (p15, p16, RB), differentiation (MYOD1), angiogenesis (THBS1, VHL), and apoptosis (Caspases, p14, DAPK) are reported and largely studied [31] (for a complete overview on key regulatory factors of DNA methylation in cancer we suggest to see Table 1 of [23]). This evidence concerns the gene RB1 and cancer.