PTGS2 and colorectal cancer: For example, Bacillus sp.-derived CGJ enhances anticancer activity by promoting γ-PGA and isoflavone derivate (genistein (GS) and daidzein(DZ))-mediated apoptosis; inhibiting pro-proliferative functions leading to DNA fragmentation and inactivation of poly (ADP-ribose) polymerase (PARP), caspase 3, cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS); and activating γ-PGA- and isoflavones (GS and DZ)-mediated 5′-adenosine monophosphate-activated protein kinase (AMPK) in HT-29 human colorectal cancer cells (Table 4; Figure 6) [9,104,105,106,107,108,109,110,111].