APOE and atherosclerosis: The best way to evaluate the influence of the dietary amino acid composition of a certain protein, keeping the rest of the nutrients unchanged, is achieved by the use of purified diets [8] when using the mouse lacking apolipoprotein E. The latter develops spontaneous atherosclerosis and fatty liver in a short period of time, and for that reason, it is considered a good animal model to test the influence of nutrients on these ailments [9,10].