Fu and colleagues constructed a multifunctional NP (MnIOMCP) for positive tumor-targeting T1-weighted and T2-weighted (T1−T2) dual-modal MRI-guided bio-PTT through bioconjugation of the CXCR4 antagonist monocyclic peptides (MCP) with MnIO NPs [62]. Here, CXCR4 is linked to neoplasm.