Further exploration using TCAGA-BRCA, SCAN-B, and METABRIC cohorts data analysis, revealed that a high S100A8 expression score was associated with the aggressive subtype TNBC or HER2+ breast cancers compared to the HR+ or HER2− breast cancer subtypes (Figure 5E–G and Table S1A). The gene discussed is ERBB2; the disease is breast carcinoma.