A variety of studies have reported that a high level of ESM-1 secretion is found in several cancers [51,52,53,54], including TNBC [55], and ESM-1 levels have been implicated to play a role in tumor metastasis, migration, and vascular invasion in human cancers by regulating the expression of MMPs [53,56,57]. Here, ESM1 is linked to neoplasm.