IL1B and melanoma: Mononuclear cells co-cultured with depigmented melanoma cells have significantly upregulated mRNA levels of IL-1β, which is known for its antiproliferative effect on melanoma cells [72], and IL-2, the cytokine which is used as an immunotherapeutic agent in disseminated malignant melanoma [73,74,75], compared to those cultured with pigmented melanoma cells.