Recently, using the SKMel-188 melanoma cell line, which represents a unique research model that allows for obtaining the results independent of individual cell line properties resulting from differences at the DNA level and thus enabling the conducting comparative studies on the biology of both forms of melanoma, we have demonstrated that CV fungus compounds cause Bcl-2- and caspase-independent cell death in non-pigmented melanoma cells [36]. The gene discussed is BCL2; the disease is melanoma.