GJC2 and lymphedema: Before describing the lymphedema-linked GJC2 mutations in detail, it should be noted that the literature regarding Cx47 mutations has been somewhat confusing as amino acid sequences were originally based on the first ATG start site for human GJC2. Over the years, increasing evidence pointed to the second ATG site for initiation of translation for human GJC2 and a progressive change was made by authors to using this site as a basis for numbering the amino acid sequence.