In addition to the strong Th2 immune response driving an increased level of Th2 cytokines and chemokines (IL-4, IL-5, IL-13, IL-31, and CCL18) [132], the Th22 response (IL-22 and S100A proteins) is also characteristic for the acute AD lesions in adults [133,134]. Here, S100A1 is linked to Alzheimer disease.