Other pathways of NKT activation include inhibition of cyclooxygenase-2 (COX-2) as seen in a study by Klatka et al. [70] The study demonstrated that in patients with laryngeal cancer, COX-2 inhibition enhances NKT cells activation and proliferation further demonstrating its utility as an immunotherapy enhancing tool. Here, PTGS2 is linked to laryngeal carcinoma.