A phase II trial of the JAK2 inhibitor ruxolitinib in R/R PTCL and CTCL reported an ORR of 23%, with responses more frequent in the AITL and Nodal Peripheral T-Cell Lymphoma with TFH Phenotype PTCL-TFH) subtypes [63]. This evidence concerns the gene JAK2 and mature T-cell and NK-cell non-Hodgkin lymphoma.