TNFRSF8 and mature T-cell and NK-cell non-Hodgkin lymphoma: Efficacy of BV in CD30+ PTCL was established in the phase III ECHELON-2 trial, which examined BV in combination with a chemotherapy backbone in previously untreated PTCL; this study compared the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, and prednisolone) to a modified CHOP with BV incorporated in place of vincristine (A+CHP).