In the group of smoking AP patients, the difference in the value of the Cu/Zn ratio was not shown, but a decrease in Zn concentration (p = 0.0275) and an increase in Cp concentration (p = 0.372) in the blood of smoking AP patients with the CG genotype compared to non-smokers with this genotype were noted (Table 6). The gene discussed is CP; the disease is alkaline phosphatase measurement.