LINGO1 and essential thrombocythemia: Regarding treatment of ET, the drugs that have shown higher efficacy are the beta-blocker propranolol and the antiepileptic drug primidone, but other drugs such as 1-octanol and octanoid acid, and drugs acting on the glutamatergic system, the extra-synaptic GABAA receptors, or LINGO-1 could be interesting therapeutic options, and injections of botulinum toxin A have shown to be useful in the treatment of refractory ET [197].