A Canadian study did not find any rare exonic variant in STK32B, PPARGC1A, and in CTNNA3 genes in a whole-exome and whole-genome sequencing study involving 14 autosomal-dominant multiplex ET families and in a targeted massive parallel sequencing study of these 3 genes in 269 ET patients and 287 controls [87]. The gene discussed is STK32B; the disease is essential thrombocythemia.