The first GWAS described a strong statistical association between the intronic rs9652490 and rs11856808 SNPs in the LINGO1 gene (chromosome 15q24.3, MIM 609791, gene ID 84894) and the risk for ET in the Icelandic population, but, after adjusting for the rs9652490 genetic effect, the association with rs11856808 disappeared, and the only confirmed in diverse studies was that of rs9652490 with ET [59]. This evidence concerns the gene LINGO1 and essential thrombocythemia.