TENM4 and essential thrombocythemia: A whole-exome sequencing followed by targeted resequencing found missense mutations in the teneurin transmembrane protein 4 gene (TENM4, ETM5, chromosome 11q14.1, MIM 610084, Gene ID 26011, TENM4 protein plays a role in establishing proper neuronal connectivity during development, and is a regulator of axon guidance and central myelination), and showed that TENM4 variants segregated in an autosomal-dominant fashion in three Spanish families with ET [107].