PPARGC1A and essential thrombocythemia: A two-stage GWAS involving 2807 ET patients and 6441 controls of European descent reported association of ET with two markers: the intronic SNP rs10937625 in the serine/threonine kinase 32B gene (STK32B, chromosome 4p16.2, Gene ID 55351; the protein encoded by this gene participates in the transfer of phosphate molecules to the oxygen atoms of serine and threonine), and rs17590046 in the PPARG coactivator 1 alpha gene (PPARGC1A, chromosome 4p15.2; MIM 604517, gen ID 10891; PPARGC1 protein acts as a transcriptional coactivator that regulates the genes involved in energy metabolism) [75].