P16/CDKN2A gene inactivation in asbestos-exposed non-small-cell lung carcinoma (NSCLC) cases, a tumor independent of tobacco smoking but associated with asbestos exposure, mainly occurs via promoter hypermethylation, loss of heterozygosity and homozygous deletion, suggesting a possible relationship with an effect of asbestos fibers [43].We observed epigenetic deregulations in the blood of MPM patients compared to that of cancer-free controls, suggesting the potential use of DNAm for risk stratification among asbestos-exposed individuals. Here, CDKN2A is linked to non-small cell lung carcinoma.