Furthermore, they found that an impaired TrkB-induced phosphorylation of PLCγ were improved in the KI mice by the normalization of striatal p75 levels although phosphorylation of ERK or Akt was not affected [26], implying TrkB/PLCγ-pathway specific action is involved in the altered behavior of the HD model animals. This evidence concerns the gene NTRK2 and Huntington disease.