Intragastric infusion of FOF for 4 weeks in acute model of AD (with intracerebroventricular injection of Aβ1–42) upregulated BDNF expression levels and activated CREB/ERK and PI3K/Akt/GSK-3β signaling pathways and was accompanied by an improvement in cognitive deficits. This evidence concerns the gene CREB1 and Alzheimer disease.