CHAT and Alzheimer disease: It was demonstrated that typical phenotypes of AD progression including loss of cholinergic neurons and reduced activity of choline acetyltransferase in the nucleus basalis of Meynert are closely related to deficits in memory and the cognitive function of AD because the cholinergic neurons in the region innervate to the hippocampus and neocortex (see the review by Cheng et al. 2021) [63].