The result indicated that long-term treatment of the non-bacterial fraction of kefir promoted a significant decrease in both measurements of mean arterial pressure (MAP) and heart rate (HR) by improving baroreflex, and reducing cardiac hypertrophy in spontaneously hypertensive rats (SHRs), likely via ACE inhibition, and reduction of the TNF-α-to-IL10 ratio. This evidence concerns the gene ACE and cardiac hypertrophy.