For instance, it has been revealed that injection of human mesenchymal stem cell-derived exosomes transfected with lncRNA KLF-3-AS1 into rats with MI (induced by ligation of coronary artery) resulted in reduction of MI area and decrease of apoptosis rate and pyroptosis-related proteins expression (such as NLRP3, ASC, and caspase-1), as well as inflammatory cytokines (IL-1β and IL-18). Here, IL18 is linked to myocardial infarction.