According to their studies, the increased PPAR activity was explained by the presence of sarquinoic and sargahydroquinoic acids that could increase adipocyte differentiation of 3T3-L1 cells, which is an unwanted side effect of natural derived ligands expected to be used in diabetes, since this feature is associated with weight gain in T2DM patients [87]. The gene discussed is PPARA; the disease is type 2 diabetes mellitus.