In addition, the homozygous ADH1C*1 allele has been discovered to be a predictor of an increased risk of HCC in ALD patients, since the ADH1C*1 allele encodes a 2.5-fold higher ethanol oxidizing capacity to generate more acetaldehyde than the ADH1C*2 allele [122]. This evidence concerns the gene ADH1C and hepatocellular carcinoma.