Thus, levels of oxidative markers, including glutathione peroxidase (GPx) and superoxide dismutase (SOD), in mitochondrial and synaptosomal fractions of postmortem frontal cortex declined significantly and correlated with Mini-Mental Status Examination scores in subjects with mild cognitive impairment, mild/moderate AD and late-stage AD. The gene discussed is SOD1; the disease is Cognitive impairment.