Using methods of molecular modeling and docking of peptides in dsDNA with arbitrary sequences, we have shown that there are almost identical hexanucleotide sequences in the lowest-energy complexes of EDR peptide with dsDNA, which are often found in the promoter regions of such genes as CASP3, NES, GAP43, APOE, SOD2, PPARA, PPARG, GDX1. The neuroprotective effect of EDR and KED peptides in AD can be defined by their ability to prevent dendritic spine elimination and neuroplasticity impairments at the molecular epigenetic level. This evidence concerns the gene APOE and Alzheimer disease.