ACE2 and infection: This was supported by showing strong expression of both ACE2 and TMPRSS2 in intestinal-type metaplasia of the esophagus and stomach, unlike normal tissue, and that organoids from biopsies of Barrett’s esophagus faithfully reproduce the in vivo histopathologic characteristics of these patients and are susceptible to infection with a chimeric virus containing the SARS-CoV-2 spike protein [60].