FNDC5 and hepatocellular carcinoma: In HCC patients, the hepatic FNDC5/Irisin mRNA levels were positively correlated with the inflammation markers tumor necrosis factor-α and interleukin-6 mRNA, as well as with the mRNA of stearoyl-CoA desaturase (SCD-1), the main enzymatic regulator of de novo lipogenesis [93].