DAPK3 and central nervous system cancer: A recent study showed that constitutive activation of PI3K and RTK signaling in a glioma cell model in Drosophila led to the activation of Drak, a close relative of the myosin II kinase DAPK3/ZIPK [254] that phosphorylated Sqh, the Drosophila ortholog of myosin II regulatory light chain [255].