ROCK2 and neoplasm: Work from Manuela Baccarini’s group has shown that binding of Raf-1 to ROCK2 reduces the kinase activity of ROCK2 and is essential for the proper regulation of adhesion and migration in several cell types [111,112,113], including blocking ROCK2-induced keratinocyte differentiation in epidermal tumorigenesis [114,115,116] and modulating ROCK2 activity at vascular endothelial (VE)-cadherin junctions during tumor-induced angiogenesis [113,117].