Evidence suggests that the CNS is also immunologically challenged—studies have shown increased numbers of ionized calcium-binding adapter molecule-1 positive (Iba1+) microglial cells (the main actors regarding the brain’s immune system) in the corpus callosum of myelin-basic protein heterozygous (MBP+/−) shiverer mice, a rodent model of schizophrenia [133]. Here, AIF1 is linked to schizophrenia.