TERT and hepatocellular carcinoma: Compared with the other etiology, HBV-related HCC frequently involves insertional mutagenesis, including mutations in KMT2B [108,109], KMT2D [104], CCND1 [104], CCNE1 [104], and TERT. Indeed, one-third of TERT dysregulation events arise from HBV integration [102].