EGFR and lung carcinoma: Also consistent with the regulators of proliferation we described above, some common gene amplification or overexpression targets found in lung carcinomas are SOX2, MYC, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) that codes for a subunit of PI3K, EGFR, and KRAS [58].