On the other hand, common sets of oncogenic drivers consisting of dominant negative TP53, myristoylated AKT serine/threonine kinase 1 (myrAKT1), retinoblastoma-associated protein-short hairpin RNA (RB1-shRNA), MYC proto-oncogene protein (MYC), and B-cell lymphoma 2 apoptosis regulator protein (BCL2) were demonstrated to transform normal human bronchial epithelial (NHBE) cells into small cell neuroendocrine cancer that had a similar transcriptional and chromatin accessibility landscape to SCLC [56]. This evidence concerns the gene RB1 and small cell lung carcinoma.