Capsaicin has been tested along with other TKIs such as erlotinib and gefitinib in some preclinical findings where the combinations were able to enhance cytotoxicity towards NSCLC by inactivating the AKT pathway and restoring enzymatic antioxidant activities such as SOD and CAT [172,173]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.