PRDX1 and idiopathic pulmonary fibrosis: One major molecular pathway is oxidative stress response: Magi et al. reported an up-regulation of antioxidant proteins in IPF, such as antioxidant peroxisomal enzyme and thioredoxin peroxidase 2 [33], later supported by Rottoli et al., who reported an upregulation of other antioxidants, such as ceruloplasmin, and an increased concentration of protein carbonyls in IPF BALF, suggesting an extended oxidative proteomic pattern [34,35].