PPARA and obesity due to melanocortin 4 receptor deficiency: Among the anti-obesity effects of Juniperus communis [104], Ramulus mori [111], Vibrunum opulus [106], Paullinia cupana [96], Peucedanum japonicum [23], Aster yomena [97], Prunus salicina [98], Eclipta alba [99], and Polygonum cuspidatum [92] evaluated on 3T3-L1 cells, Eclipta alba showed the highest activity as it decreased the expression of PPARα (1.9 fold), C/EBPα (1.8 fold), FAS (1.4 fold) and FABP4 (1.8 fold) and also decreased the concentration of lipids in terms of cholesterol and triglycerides in these adipocytes.