The nanoparticles isolated from red grape seed, especially cellulose nanocrystals (CNC), had a significant positive effect on obesity and hyperlipidemia compared to grape seeds powder, while the chemical constituents of the crude leaf extract of Vitis vinifera [100] inhibited pancreatic lipase, affecting lipid metabolism and consequently obesity. This evidence concerns the gene PNLIP and obesity due to melanocortin 4 receptor deficiency.