Of interest, the strongest associations resulted with routine parameters such as glucose, total proteins, white blood cells, albumin, and especially with total-tau protein, a marker of neuronal injury whose CSF levels proportionally increase with axonal degeneration in neurons, as occurs in AD [19], prion diseases, and other acute neurological disorders (e.g., status epilepticus) [20]. The gene discussed is MAPT; the disease is Alzheimer disease.