TMPRSS2 and cancer: Mechanistically, the interaction between the host immune environment and cancer or SARS-CoV-2 infections uses similar pathways, such as hypercoagulability, dysregulated immune response, elevated cytokine levels, altered expression ACE-2 and TMPRSS2, and prothrombotic status, which bring the human body into severe disequilibrium and may aggravate the effects of SARS-CoV-2 in some cancer patients [15].