AGTR1 and diabetic kidney disease: Furthermore, a case–control study in a large cohort of T1DM patients from Denmark, Finland, France and Sweden, found that the AA genotype of the rs5186 AGTR1 polymorphism significantly increased the DKD risk in male patients (OR = 1.27; 95% CI = 1.02–1.58, p = 0.03), after adjustment for multiple confounders, whereas no significant associations were noted in women [192].