Some studies have also evidenced a predominant expression of GPER-1 in renal tubular cells [106,107], and therapy with GPER-1 agonist in female mice with salt-sensitive disease has been reported to improve glomerular function and hypertrophy and to reduce proteinuria [108], thus suggesting a key role of this receptor in kidney disorders and, probably, in DKD. Here, GPER1 is linked to diabetic kidney disease.