SLC5A1 and type 2 diabetes mellitus: Thus, recent guidelines recommend the use of inhibitors of sodium-glucose cotransporter 1 (SGLT2i) and glucagonlike protein 1 receptor agonists (GLP1Ras) in T2DM subjects with DKD, on the wave of the encouraging results of many cardiovascular outcome trials (CVOTs) and dedicated investigations in patients with CKD with or without T2DM, but very few of them have specifically evaluated sex or gender differences [227,228].