In a subsequent work, Teixeira A.L. et al. (2015) demonstrated that the combined effect of EGF + 61G > A and TGFB1 + 869T > C polymorphisms, associated with higher levels of EGF and lower TGFβ1 production, finally had an unfavorable synergic effect on the progression-free interval and overall survival of RCC patients [55]. This evidence concerns the gene TGFB1 and renal cell carcinoma.