Finally, the EORTC-GIMEMA AML-19 study showed an increase in OS rate in AML patients treated with GO-containing therapy, compared to best supportive care (BSC) when patients with newly diagnosed CD33-positive AML were treated with GO monotherapy at 6 mg/m2 on day 1 and 3 mg/m2 on day 8 [39]. Here, CD33 is linked to acute myeloid leukemia.