KIR2DL3 and neoplasm: We have previously generated transgenic mice expressing the human inhibitory receptor KIR2DL3 (TgKIR mice) [28,29,30], which were crossed with RAG-1 KO animals that lack T and B cells (TgKIR-RAG1KO) to generate recipients for human tumor cells expressing the MHC class I molecule HLA-Cw3, a ligand for KIR2DL3.