We propose that, similar to cebranopadol [44,51], the NOP receptor full agonism of KGNOP1 is able to positively suppress the reinforcement acquisition induced by the MOR agonism, as KGNOP1 was devoid of reinforcing effects, withdrawal syndrome, and locomotor dysfunction, shown in this study, as well as a lower propensity for respiratory depression when given systemically to rodents [22,23]. This evidence concerns the gene OPRM1 and Respiratory insufficiency due to muscle weakness.