In the past, several studies have already been performed on the crosslink between C3 deficiency and angiogenesis: In a model of age-related macular degeneration (AMD), inducing choroidal neovascularization (CNV) by laser photocoagulation, Bora et al. showed that C3-deficient mice were protected against CNV [32]. This evidence concerns the gene C3 and choroidal neovascularization.