However, we do not want to omit the data from Nozaki et al., who showed in an accelerated model of age-related macular degeneration that genetic ablation of C5aR or C3aR resulted in a reduced recruitment of leukocytes and reduced VEGF levels along with reduced choroidal neovascularization [25]. The gene discussed is VEGFA; the disease is age-related macular degeneration.