ISG15 and familial pancreatic carcinoma: To explore the relationship between H-1PV and innate immunity in pancreatic cancer, we infected nine PDAC cell lines and monitored the expression of three marker ISGs (ISG15, IFITM1, OAS1) and three marker HERVs known for establishing an antiviral state in tumor cells (HERV-K env, HERV-W env, HERV-W pol) [43].