IFNA1 and neoplasm: Among other effects, this blockade disabled the cGAS (cyclic GMP-AMP synthase)/STING-mediated sensing of nucleic acids—an afferent interferogenic pathway also activated by gemcitabine, a standard genotoxic anti-PDAC drug with broad antiviral activity and the ability to trigger IFN-dependent immunity in dying tumor cells [30,31,32,33,34].