We had previously reported restoration of obstructed tumor blood flow by using NO donors, L-Arg, NG, and HU [7,10,11,12,25], and micellar forms of CO donors such as SMA/CORM2 and PEG-hemin or an inducer of heme oxygenase-1 (HO-1), which also generates CO [26,27]. The gene discussed is HMOX1; the disease is neoplasm.