NFKB1 and hepatocellular carcinoma: In another recent report, it was shown that a cell cycle-related kinase unique to HCC upregulates IL-6 production and activates nuclear factor-κB (NF-κB) by enhancing the zeste homolog 2 (EZH2) enzyme, resulting in the accumulation of polymorphonuclear MDSCs with potent T cell suppression in the TME [66].