Furthermore, subsets of immune cells such as MDSCs, tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), cancer-associated fibroblasts (CAFs), regulatory T cells (Tregs), tumor-infiltrating lymphocytes (TILs), and CD8+ cytotoxic T lymphocytes (CTLs) are also critical immunosuppressive components in the TME of HCC (Table 1). This evidence concerns the gene CD8A and hepatocellular carcinoma.