Further up-to-date HCC gene expression and exosome analysis suggested that HCC can be categorized into the MS1 group with TP53 mutation, a robust cancer cell proliferation, and chromosomal instability, which were associated with poor prognosis; the MS2 group with catenin β1 (CTNNB1) mutation and high DNA methylation level; and the MS3 group, which was strongly associated with metabolic syndrome [203]. Here, TP53 is linked to hepatocellular carcinoma.