In addition, hypoxia-inducible factor 1α (HIF-1α) promotes MDSC accumulation by converting extracellular ATP to 5′ AMP through ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) overexpression in HCC cells [68]. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.