The impact of TILs on the prognosis of HCC is controversial, but a recent meta-analysis has shown that the density of FOXP3+, CD8+, CD3+, and granzyme B+ lymphocytes in TILs is significantly associated with improved survival, and these subsets can serve as prognostic biomarkers in HCC [117]. This evidence concerns the gene CD8A and hepatocellular carcinoma.